Immune thrombocytopenia (ITP) is a type of thrombocytopenic purpura defined as isolated low platelet count (thrombocytopenia) with normal bone marrow and. Amaç: İdiopatik trombositopenik purpura (ITP); trombositopenî, trombosit ömründe kısalma, plazmada anti-trombosit antikorların varlığı ve kemik iliğinde. Immune thrombocytopenic purpura (ITP) is a bleeding disorder in which the immune system destroys platelets, which are necessary for normal.

Author: Gukree Doujora
Country: Estonia
Language: English (Spanish)
Genre: Relationship
Published (Last): 13 October 2012
Pages: 30
PDF File Size: 14.69 Mb
ePub File Size: 3.33 Mb
ISBN: 920-7-71868-495-8
Downloads: 39119
Price: Free* [*Free Regsitration Required]
Uploader: Zulugore

Platelet transfusion alone is normally not recommended except in an emergency, and is usually unsuccessful in producing a long-term platelet count increase. Other immunosuppresants, which are steroid sparing drugs like mycophenolate mofetil and azathioprine, are becoming more popular for their effectiveness.

Recommendations of the American Society of Hematology. This observation has led to the development of a class of ITP-targeted medications referred to as thrombopoietin receptor agonists. Most cases respond during the 1 st week of treatment. In mild cases, only careful observation may be required but very low counts or significant bleeding may prompt treatment with corticosteroidsintravenous immunoglobulin tronbosit, anti-D immunoglobulinor immunosuppressive medications.

Idiopathic thrombocytopenic purpura

This article has been cited by other articles in PMC. Increased antiplatelet T helper lymphocyte reactivity in patients with autoimmune thrombocytopenia. However, while sometimes effective, it is costly and produces improvement that generally lasts less than a month.


A report of 66 cases. ITP is diagnosed by a low platelet count in a complete blood count a common blood test.

Immune thrombocytopenic purpura (ITP): MedlinePlus Medical Encyclopedia

ITP is usually chronic in adults [40] and the probability of durable remission is 20—40 percent. Infobox medical condition new All trombsit lacking reliable references Articles lacking reliable references from July With rare exceptions, there is usually no need to treat based on platelet counts.

Patients with mild, asymptomatic thrombocytopenia, discovered incidentally on a routine blood count, should not be treated. Corticosteroids, typically prednisone, are the backbone of the initial treatment.

There is increasing use of immunosuppressants such as mycophenolate mofetil and azathioprine because of their effectiveness. With epidermal involvement Eczematous contact dermatitis atopic dermatitis seborrheic dermatitis stasis dermatitis lichen simplex chronicus Darier’s disease glucagonoma syndrome langerhans cell histiocytosis lichen sclerosus pemphigus foliaceus Wiskott—Aldrich syndrome Zinc deficiency. Dapsone also called diphenylsulfone, DDS, or avlosulfon is an anti-infective sulfone drug.

Immune thrombocytopenic purpura – Wikipedia

History of presenting illness revealed that patient noticed bleeding from his gums in lower front teeth region approximately 2 weeks before reporting tfombosit department and patient was having purpuric spots on body legs, hands, and neck since past 2 months. The diagnosis of ITP is a process of exclusion. In a fifth, the platelet count normalized completely; this response rate is similar to that found in treatment with rituximab, which is more expensive and less safe.


No significant difference was noted in the rate of survival between males and females. Retrieved from ” https: Another option, suitable for Puepura patients with functional spleens is intravenous administration of Purura D immune globulin [Human; Anti-D]. The clinical presentation may be acute with severe bleeding, or insidious with slow development with mild or no symptoms.

Cellular immune mechanisms in autoimmune thrombocytopenic purpura: Health Topics A-Z Read more. Sudden and severe loss of blood from the digestive tract may occur. All the petechial lesions were completely resolved over the neck, arm, and forearms.

Durable remission following splenectomy is achieved in 75 percent of ITP cases. Two distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults.

There is marked variability in the clinical presentation of ITP. Platelet transfusions may be performed in newborns, depending on the degree of thrombocytopenia. General care includes explaining ITP to the patient and advising him or her to watch for bruising, petechiae, or other signs of recurrence.